Opportunity Information: Apply for RFA NS 19 026
The funding opportunity titled "Clinical and Biological Measures of TBI-related dementia including Chronic Traumatic Encephalopathy (CTE) (R01 Clinical Trial Not Allowed)" (Funding Opportunity Number RFA-NS-19-026) is a National Institutes of Health (NIH) research grant announcement from the U.S. Department of Health and Human Services. It supports R01 research projects focused on understanding how traumatic brain injury (TBI) can lead, over time, to progressive neurodegeneration and worsening cognitive decline that increases the risk for dementia and/or traumatic encephalopathy syndrome (TES). TES is described as the clinical syndrome that corresponds to the neuropathological diagnosis of chronic traumatic encephalopathy (CTE), meaning the FOA is aimed at bridging what can be observed and measured in living people (clinical signs, imaging, biomarkers) with disease processes that are often confirmed definitively only through pathology.
The central scientific goal is to sharpen the distinction between two different long-term outcomes after TBI: (1) static-chronic TBI-related cognitive impairment, where difficulties persist but do not clearly worsen in a degenerative pattern, and (2) progressive neurodegeneration that unfolds over time and is associated with TES and dementia. The FOA is seeking studies that can clarify underlying mechanisms and pathophysiology, improve clinical characterization of symptoms and trajectories, and identify measurable indicators that track or predict who is most likely to develop progressive decline. In practice, this means projects should look for clinical measures, neuropsychological patterns, neuroimaging features, physiological readouts, and biological markers (for example, blood-based, CSF-based, or other biospecimen-derived measures) that help explain and differentiate progressive disease processes from stable post-injury deficits.
A key expectation is that research be conducted in existing, well-characterized cohorts of people with a history of TBI. Rather than building entirely new samples from scratch, applicants are expected to leverage populations that already have meaningful baseline characterization and infrastructure, and that can continue to be followed longitudinally. The cohorts should be enriched for individuals at increased risk of cognitive impairment or dementia, which helps ensure the studies are positioned to observe enough cases of decline and progression to identify meaningful associations and trajectories. The longitudinal component is essential because the FOA is explicitly concerned with progressive change over time and with differentiating long-standing but non-progressive impairment from degenerative decline.
Another defining feature of this opportunity is its emphasis on broad data sharing. Investigators are expected to share clinical data, neuroimaging data, physiological data, and biospecimen-related data in a way that accelerates the broader field. This reflects the idea that TBI-related neurodegeneration, TES, and dementia risk are complex and likely require large, harmonized datasets and cross-cohort comparisons to validate biomarkers, replicate findings, and develop robust clinical characterization. Data sharing is therefore not treated as an optional add-on, but as a critical element intended to maximize the impact of each funded award.
From an administrative and eligibility standpoint, this is a discretionary grant mechanism under NIH with a health focus (CFDA numbers 93.853 and 93.866). A wide range of applicants are eligible, including state, county, and local governments; public and private institutions of higher education; tribal governments and tribal organizations; nonprofits (with or without 501(c)(3) status); public housing authorities/Indian housing authorities; and for-profit organizations (including small businesses). The FOA is explicitly labeled "Clinical Trial Not Allowed," which signals that while the work can involve human participants and longitudinal observational follow-up, it should not be designed as an interventional clinical trial evaluating the effects of an assigned treatment or preventive strategy.
In terms of funding scope and scale, the opportunity listed an award ceiling of $1,000,000 and an anticipated number of four awards. The FOA was created on February 25, 2019, with an original closing date of April 15, 2019. Overall, the program is positioned to move the field toward clearer biological and clinical definitions of TBI-related progressive neurodegeneration, better tools for identifying at-risk individuals, and shared datasets that enable faster validation and consensus-building around measures relevant to TES, CTE-related clinical presentation, and dementia outcomes after TBI.Apply for RFA NS 19 026
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical and Biological Measures of TBI-related dementia including Chronic Traumatic Encephalopathy (CTE) (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
- This funding opportunity was created on Feb 25, 2019.
- Applicants must submit their applications by Apr 15, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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