Opportunity Information: Apply for PA 19 055
The National Institutes of Health (NIH) Research Project Grant (Parent R01 Clinical Trial Required), funding opportunity number PA-19-055, is a discretionary grant mechanism designed to support a single, well-defined research effort that is discrete, specific, and limited in scope, led by one or more investigators with relevant expertise. This is the classic NIH R01-style award, meaning the emphasis is on investigator-driven science where the applicant proposes a clear set of aims, a strong scientific rationale, and a feasible plan to carry out a substantial research project. What makes this particular parent announcement distinct is that it requires the application to include at least one clinical trial, as NIH defines that term. In practical terms, applicants need to propose research in which human participants are prospectively assigned to an intervention (which can include behavioral, educational, or other types of interventions, not only drugs or devices) to evaluate effects on health-related biomedical or behavioral outcomes.
Projects submitted under this announcement must align with the scientific missions and program priorities of one or more participating NIH Institutes and Centers (ICs). That alignment matters because NIH is not a single monolithic funder; each IC has its own disease areas, populations, methods, and strategic interests. Applicants are expected to ensure that their topic is a good fit for an IC that is participating in the announcement, and to pay attention to NIH "Related Notices" that may place additional constraints on what certain ICs will accept through this mechanism. A key nuance highlighted in the description is that some ICs only accept applications here if the proposed clinical trial is mechanistic in nature, meaning it is designed to understand biological, physiological, or behavioral mechanisms and meets NIHs definition of a clinical trial, rather than being primarily confirmatory, pragmatic, or focused on broad effectiveness in real-world settings. Because those IC-specific rules can affect eligibility and peer review expectations, applicants typically need to verify fit early, sometimes by contacting the relevant NIH program officer before submission.
The eligible applicant pool is broad and includes many types of domestic U.S. organizations and government entities, such as state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and public housing authorities, including Indian housing authorities. A wide range of nonprofit organizations are eligible as well, including both 501(c)(3) nonprofits and nonprofits without 501(c)(3) status, as are for-profit organizations (other than small businesses) and small businesses. The announcement also explicitly calls out additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). It further includes Indian/Native American Tribal Governments that are not federally recognized, eligible federal government agencies, faith-based or community-based organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations) and regional organizations, underscoring NIHs intent to allow many institution types to compete when the science and trial design are compelling and compliant with NIH policy.
From an administrative standpoint, the opportunity is categorized under the Health (and related) funding activity domain and is associated with multiple CFDA numbers, reflecting the fact that many NIH components may fund awards under this parent announcement depending on topic area. The source information lists an original closing date of 2020-05-24 and a creation date of 2018-11-05; however, in practice NIH parent FOAs often run across multiple receipt cycles and may be reissued or updated, so applicants generally need to verify current submission windows and any updates in the active FOA and related notices. The listing does not specify an award ceiling or expected number of awards in the provided data, which is common for NIH opportunities where award size and volume depend heavily on scientific scope, institute budgets, and the number of meritorious applications in a given cycle.
Overall, this opportunity is best viewed as a flexible, investigator-initiated R01 pathway specifically for proposals that include at least one NIH-defined clinical trial and that clearly match the mission of a participating NIH Institute or Center. The main takeaways for prospective applicants are that a clinical trial is not optional under this announcement, IC-specific acceptance criteria can narrow what kinds of trials are allowed (especially around mechanistic versus other trial types), and eligibility is broad enough to include universities, governments, nonprofits, community-based groups, tribal entities, U.S. territories, and certain foreign organizations, provided all NIH requirements for human subjects research and clinical trials are met.Apply for PA 19 055
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Research Project Grant (Parent R01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.172, 93.173, 93.213, 93.233, 93.273, 93.279, 93.307, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.855, 93.859, 93.866, 93.867.
- This funding opportunity was created on 2018-11-05.
- Applicants must submit their applications by 2020-05-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 19 055) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed) Apply for PA 19 053 Funding Number: PA 19 053 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required) Apply for PA 19 054 Funding Number: PA 19 054 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Apply for PA 19 052 Funding Number: PA 19 052 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $50,000 |
| NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) Apply for PA 19 091 Funding Number: PA 19 091 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) Apply for PA 19 092 Funding Number: PA 19 092 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 088 Funding Number: PA 19 088 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed) Apply for PAR 19 098 Funding Number: PAR 19 098 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required) Apply for PA 19 121 Funding Number: PA 19 121 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed) Apply for PA 19 122 Funding Number: PA 19 122 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Required) Apply for PA 19 131 Funding Number: PA 19 131 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed) Apply for PA 19 132 Funding Number: PA 19 132 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| U.S.-China Program for Biomedical Collaborative Research (R01 Clinical Trial Optional) Apply for RFA CA 19 009 Funding Number: RFA CA 19 009 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $150,000 |
| Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed) Apply for PAR 19 158 Funding Number: PAR 19 158 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Summer Research Education Experience Program (Clinical Trials Not Allowed R25) Apply for PAR 19 164 Funding Number: PAR 19 164 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $100,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 19 187 Funding Number: PA 19 187 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Summer Research Education Experience Program (R25 Clinical Trial Not Allowed) Apply for PAR 19 197 Funding Number: PAR 19 197 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $100,000 |
| Building Interdisciplinary Research Careers in Women's Health (BIRCWH); K12 Clinical Trial Optional Apply for RFA OD 19 020 Funding Number: RFA OD 19 020 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $600,000 |
| Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R21 Clinical Trial Optional) Apply for PAR 19 252 Funding Number: PAR 19 252 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Populations (R01 Clinical Trial Optional) Apply for PAR 19 250 Funding Number: PAR 19 250 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R01 Clinical Trial Optional) Apply for PAR 19 251 Funding Number: PAR 19 251 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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