Opportunity Information: Apply for PAR 24 037
The HIV Vaccine Research and Design (HIVRAD) Program (P01 Clinical Trial Not Allowed), Funding Opportunity Number PAR-24-037, is a National Institutes of Health (NIH) discretionary grant opportunity designed to fund coordinated, multi-component research programs focused on AIDS prophylactic vaccine discovery. The emphasis is on tackling key scientific questions that move HIV vaccine concepts forward at the discovery and preclinical stages, using a structure that supports multiple integrated projects under one overall program. Because it is a P01 mechanism, the expectation is that applicants will propose a multi-disciplinary team and a set of interrelated research components that work together toward shared vaccine discovery goals, rather than a single standalone project.
The scientific scope centers on research relevant to preventing HIV infection through vaccination (prophylactic vaccine research), with room for extensive evaluation of vaccine concepts in non-human primate models when appropriate. In practical terms, this means applicants can propose substantial preclinical testing and iterative design work, including studies that help refine immunogen design, evaluate immune responses, and compare vaccine strategies in rigorous animal model systems. At the same time, the notice clearly states "Clinical Trial Not Allowed," which signals that the funded work must not include clinical trials; the program is aimed at discovery and preclinical development rather than human efficacy or interventional clinical studies.
From an administrative standpoint, this opportunity is categorized under the Health funding activity area and is associated with CFDA number 93.855. The funding instrument is a grant, and the posted award ceiling is $2,500,000, indicating support for relatively large, complex programs consistent with the P01 format. The opportunity was created on 2023-10-04, and the original closing date listed is 2026-03-13, giving prospective applicants a defined window to plan and submit an application aligned with NIH requirements for multi-project awards.
Eligibility is broad and includes many types of U.S. organizations and governments, reflecting NIH's intent to attract strong multidisciplinary teams regardless of institutional type. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in that specific nonprofit category); for-profit organizations (other than small businesses); and small businesses. The notice also highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations). This range signals that NIH is open to applications led by domestic or international institutions, as well as collaborations that bring together specialized capabilities in immunology, virology, structural biology, computational design, vaccinology, and animal model research.
Overall, PAR-24-037 supports ambitious, team-based HIV vaccine discovery programs built around multiple integrated research components, potentially including extensive non-human primate evaluation, with the clear boundary that clinical trials are not part of the allowable scope.Apply for PAR 24 037
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "HIV Vaccine Research and Design (HIVRAD) Program (P01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2023-10-04.
- Applicants must submit their applications by 2026-03-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): PAR-24-037 HIV Vaccine Research and Design (HIVRAD) Program (P01 Clinical Trial Not Allowed)
What is the PAR-24-037 funding opportunity?
PAR-24-037 is a National Institutes of Health (NIH) discretionary grant opportunity under the HIV Vaccine Research and Design (HIVRAD) Program. It supports coordinated, multi-component research programs focused on AIDS prophylactic vaccine discovery, emphasizing discovery and preclinical stages rather than clinical trials.
Which NIH grant mechanism is used for this opportunity?
This opportunity uses the P01 mechanism, which is a multi-project program grant designed to support an integrated set of interrelated research components under one overall program.
What does a P01 program structure imply for applicants?
Because this is a P01, NIH expects a multi-disciplinary team proposing multiple integrated and interrelated projects or components that work together toward shared HIV vaccine discovery goals, rather than a single standalone research project.
What is the main scientific focus of HIVRAD under PAR-24-037?
The core focus is prophylactic HIV vaccine research: research intended to prevent HIV infection through vaccination, with emphasis on moving HIV vaccine concepts forward through discovery and preclinical development.
Are clinical trials allowed under this funding opportunity?
No. The opportunity is explicitly labeled "Clinical Trial Not Allowed," which means the funded work must not include clinical trials and should remain at the discovery and preclinical stages rather than human interventional studies.
Is non-human primate (NHP) research within scope?
Yes. The opportunity allows room for extensive evaluation of vaccine concepts in non-human primate models when appropriate, supporting rigorous preclinical testing and comparison of vaccine strategies in animal model systems.
What types of preclinical activities are emphasized?
The description emphasizes substantial preclinical testing and iterative design work, including studies to refine immunogen design, evaluate immune responses, and compare vaccine strategies using rigorous animal models (including non-human primates when appropriate).
What is the funding instrument for PAR-24-037?
The funding instrument is a grant.
What is the award ceiling for this opportunity?
The posted award ceiling is $2,500,000, which aligns with support for relatively large, complex, multi-component programs typical of the P01 format.
What is the funding activity area for this opportunity?
The opportunity is categorized under the Health funding activity area.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 93.855.
When was this funding opportunity created?
It was created on 2023-10-04.
What is the original closing date listed for PAR-24-037?
The original closing date listed is 2026-03-13, providing a defined window for applicants to plan and submit an application consistent with NIH multi-project award requirements.
What types of organizations are eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and governments, reflecting NIH's intent to attract strong multidisciplinary teams across institutional types.
Are U.S. state, county, or city governments eligible?
Yes. Eligible applicants include state governments, county governments, and city or township governments.
Are special district governments eligible?
Yes. Special district governments are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are included as eligible applicants.
Are public institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education are eligible.
Are private institutions of higher education eligible?
Yes. Private institutions of higher education are eligible.
Are Native American tribal governments eligible?
Yes. Federally recognized Native American tribal governments are eligible. Tribal organizations that are not federally recognized are also listed as eligible.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with or without 501(c)(3) status are eligible, as long as they are not institutions of higher education in that specific nonprofit category referenced in the notice.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also eligible under a separate listed category.
Are small businesses eligible?
Yes. Small businesses are explicitly listed as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are included among eligible applicants.
Are minority-serving institutions (MSIs) highlighted as eligible?
Yes. The notice highlights additional eligible categories including Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are specifically highlighted as eligible applicant categories.
Are U.S. federal agencies eligible?
Yes. Eligible federal agencies are included among the additional eligible applicant categories.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicant categories.
Are regional organizations eligible?
Yes. Regional organizations are included among eligible applicant categories.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-U.S. entities (foreign organizations) are explicitly listed as eligible applicants, indicating that NIH is open to applications led by international institutions as well as collaborations spanning countries.
What kinds of scientific expertise or disciplines are implied to be relevant for teams?
The notice signals openness to multidisciplinary collaborations that bring together specialized capabilities in areas such as immunology, virology, structural biology, computational design, vaccinology, and animal model research, consistent with the integrated nature of a P01 program.
What is the overall purpose of this opportunity in plain terms?
It is designed to fund ambitious, team-based HIV vaccine discovery programs made up of multiple integrated research components, potentially including extensive non-human primate evaluation, with a clear boundary that clinical trials are not part of the allowable scope.
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